Have you been thinking about trying Chantix to quit smoking? Chantix (varenicline tartrate) is a non-nicotine prescription medicine that was developed by Pfizer, Inc. specifically to help people quit smoking. varenicline tartrate works on two levels. First, it partially activates sites in the brain, known as nicotinic acetylcholine receptors, that are affected by nicotine. This gives new ex-smokers mild nicotine-like effects and eases symptoms of nicotine withdrawal. Second, varenicline tartrate has the unique ability to stop nicotine from attaching to those nicotine receptors if you do smoke while using it. Chantix has been discontinued however varenicline tartrate the generic form has been approved and is available.